Title |
Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer
|
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Published in |
PLOS ONE, October 2009
|
DOI | 10.1371/journal.pone.0007524 |
Pubmed ID | |
Authors |
Rebecca Davis, Wasia Rizwani, Sarmistha Banerjee, Michelle Kovacs, Eric Haura, Domenico Coppola, Srikumar Chellappan |
Abstract |
Nicotine is the major addictive component of tobacco smoke. Although nicotine is generally thought to have limited ability to initiate cancer, it can induce cell proliferation and angiogenesis in a variety of systems. These properties might enable nicotine to facilitate the growth of tumors already initiated. Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 3% |
Norway | 1 | 1% |
Switzerland | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 85 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 15% |
Researcher | 11 | 12% |
Student > Master | 11 | 12% |
Student > Bachelor | 10 | 11% |
Other | 9 | 10% |
Other | 22 | 24% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 23% |
Biochemistry, Genetics and Molecular Biology | 17 | 19% |
Agricultural and Biological Sciences | 17 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Environmental Science | 4 | 4% |
Other | 10 | 11% |
Unknown | 17 | 19% |