Title |
Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2
|
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Published in |
PLOS ONE, October 2009
|
DOI | 10.1371/journal.pone.0007411 |
Pubmed ID | |
Authors |
Maximiliano J. Jimenez-Dalmaroni, Nengming Xiao, Adam L. Corper, Petra Verdino, Gary D. Ainge, Dave S. Larsen, Gavin F. Painter, Pauline M. Rudd, Raymond A. Dwek, Kasper Hoebe, Bruce Beutler, Ian A. Wilson |
Abstract |
Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved in many biological processes, such as platelet biology, angiogenesis and in the aetiopathology of atherosclerosis and cardiovascular diseases. Toll-like receptors (TLRs) are one of the most important receptors of the innate immune system. Their main function is the recognition of conserved structure of microorganisms. This recognition triggers signaling pathways that activate transcription of cytokines and co-stimulatory molecules which participate in the generation of an immune response against microbes. In particular, TLR2 has been shown to recognize a broad range of ligands. Recently, we showed that CD36 serves as a co-receptor for TLR2 and enhances recognition of specific diacylglycerides derived from bacteria. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Netherlands | 1 | 1% |
United Kingdom | 1 | 1% |
Denmark | 1 | 1% |
Japan | 1 | 1% |
Unknown | 94 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 23% |
Researcher | 21 | 21% |
Student > Master | 12 | 12% |
Professor > Associate Professor | 7 | 7% |
Student > Bachelor | 6 | 6% |
Other | 16 | 16% |
Unknown | 14 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 42% |
Medicine and Dentistry | 12 | 12% |
Biochemistry, Genetics and Molecular Biology | 10 | 10% |
Immunology and Microbiology | 8 | 8% |
Chemistry | 3 | 3% |
Other | 8 | 8% |
Unknown | 16 | 16% |