Title |
miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases
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Published in |
PLOS ONE, September 2009
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DOI | 10.1371/journal.pone.0007181 |
Pubmed ID | |
Authors |
Derek M. Dykxhoorn, Yichao Wu, Huangming Xie, Fengyan Yu, Ashish Lal, Fabio Petrocca, Denis Martinvalet, Erwei Song, Bing Lim, Judy Lieberman |
Abstract |
The development of metastases involves the dissociation of cells from the primary tumor to penetrate the basement membrane, invade and then exit the vasculature to seed, and colonize distant tissues. The last step, establishment of macroscopic tumors at distant sites, is the least well understood. Four isogenic mouse breast cancer cell lines (67NR, 168FARN, 4TO7, and 4T1) that differ in their ability to metastasize when implanted into the mammary fat pad are used to model the steps of metastasis. Only 4T1 forms macroscopic lung and liver metastases. Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 1% |
Germany | 1 | <1% |
India | 1 | <1% |
Australia | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
Unknown | 186 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 56 | 29% |
Student > Ph. D. Student | 46 | 24% |
Student > Master | 19 | 10% |
Student > Bachelor | 15 | 8% |
Professor > Associate Professor | 13 | 7% |
Other | 27 | 14% |
Unknown | 17 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 72 | 37% |
Biochemistry, Genetics and Molecular Biology | 50 | 26% |
Medicine and Dentistry | 28 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Engineering | 4 | 2% |
Other | 12 | 6% |
Unknown | 23 | 12% |