Title |
Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor
|
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Published in |
PLOS ONE, October 2009
|
DOI | 10.1371/journal.pone.0007112 |
Pubmed ID | |
Authors |
Alex N. Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp |
Abstract |
The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of anticancer agents. To date our knowledge of catalytic domain structures of the PIM kinase family is limited to PIM1 which has been extensively studied and which shares about 50% sequence identity with PIM2. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Greece | 1 | 1% |
Germany | 1 | 1% |
Canada | 1 | 1% |
Unknown | 70 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 23% |
Researcher | 12 | 16% |
Student > Bachelor | 9 | 12% |
Other | 8 | 11% |
Student > Master | 8 | 11% |
Other | 8 | 11% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 20 | 27% |
Agricultural and Biological Sciences | 17 | 23% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Medicine and Dentistry | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 3 | 4% |
Unknown | 17 | 23% |