| Title |
Chlorproguanil−Dapsone−Artesunate versus Artemether−Lumefantrine: A Randomized, Double-Blind Phase III Trial in African Children and Adolescents with Uncomplicated Plasmodium falciparum Malaria
|
|---|---|
| Published in |
PLOS ONE, August 2009
|
| DOI | 10.1371/journal.pone.0006682 |
| Pubmed ID | |
| Authors |
Zul Premji, Rich E. Umeh, Seth Owusu-Agyei, Fabian Esamai, Emmanuel U. Ezedinachi, Stephen Oguche, Steffen Borrmann, Akintunde Sowunmi, Stephan Duparc, Paula L. Kirby, Allan Pamba, Lynda Kellam, Robert Guiguemdé, Brian Greenwood, Stephen A. Ward, Peter A. Winstanley |
| Abstract |
Chlorproguanil-dapsone-artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 3% |
| Vietnam | 1 | <1% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 124 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 14% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 14 | 11% |
| Student > Ph. D. Student | 12 | 9% |
| Other | 12 | 9% |
| Other | 31 | 23% |
| Unknown | 26 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 32% |
| Biochemistry, Genetics and Molecular Biology | 14 | 11% |
| Agricultural and Biological Sciences | 13 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Nursing and Health Professions | 6 | 5% |
| Other | 21 | 16% |
| Unknown | 29 | 22% |