| Title |
Does the Clock Make the Poison? Circadian Variation in Response to Pesticides
|
|---|---|
| Published in |
PLOS ONE, July 2009
|
| DOI | 10.1371/journal.pone.0006469 |
| Pubmed ID | |
| Authors |
Louisa A. Hooven, Katherine A. Sherman, Shawn Butcher, Jadwiga M. Giebultowicz |
| Abstract |
Circadian clocks govern daily physiological and molecular rhythms, and putative rhythms in expression of xenobiotic metabolizing (XM) genes have been described in both insects and mammals. Such rhythms could have important consequences for outcomes of chemical exposures at different times of day. To determine whether reported XM gene expression rhythms result in functional rhythms, we examined daily profiles of enzyme activity and dose responses to the pesticides propoxur, deltamethrin, fipronil, and malathion. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Argentina | 1 | <1% |
| India | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 100 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 27% |
| Researcher | 30 | 27% |
| Student > Master | 14 | 13% |
| Student > Doctoral Student | 6 | 5% |
| Professor > Associate Professor | 6 | 5% |
| Other | 16 | 15% |
| Unknown | 8 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 66 | 60% |
| Environmental Science | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Medicine and Dentistry | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 6 | 5% |
| Unknown | 14 | 13% |