| Title |
Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo
|
|---|---|
| Published in |
PLOS ONE, July 2009
|
| DOI | 10.1371/journal.pone.0006278 |
| Pubmed ID | |
| Authors |
Beatrice Cousin, Emmanuel Ravet, Sandrine Poglio, Fabienne De Toni, Mélanie Bertuzzi, Hubert Lulka, Ismahane Touil, Mireille André, Jean-Louis Grolleau, Jean-Marie Péron, Jean-Pierre Chavoin, Philippe Bourin, Luc Pénicaud, Louis Casteilla, Louis Buscail, Pierre Cordelier |
| Abstract |
Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. Disrupting this homeostasis can induce aberrant cell proliferation, adhesion, function and migration that might promote malignant behavior. Indeed, aberrant stromal-epithelial interactions contribute to pancreatic ductal adenocarcinoma (PDAC) spread and metastasis, and this raises the possibility that novel stroma-targeted therapies represent additional approaches for combating this malignant disease. The aim of the present study was to determine the effect of human stromal cells derived from adipose tissue (ADSC) on pancreatic tumor cell proliferation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 118 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 23% |
| Student > Master | 21 | 17% |
| Researcher | 18 | 14% |
| Student > Bachelor | 16 | 13% |
| Other | 8 | 6% |
| Other | 14 | 11% |
| Unknown | 19 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 27% |
| Medicine and Dentistry | 29 | 23% |
| Biochemistry, Genetics and Molecular Biology | 24 | 19% |
| Immunology and Microbiology | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 8 | 6% |
| Unknown | 22 | 18% |