| Title |
IL-12 Can Target Human Lung Adenocarcinoma Cells and Normal Bronchial Epithelial Cells Surrounding Tumor Lesions
|
|---|---|
| Published in |
PLOS ONE, July 2009
|
| DOI | 10.1371/journal.pone.0006119 |
| Pubmed ID | |
| Authors |
Irma Airoldi, Emma Di Carlo, Claudia Cocco, Emanuela Caci, Michele Cilli, Carlo Sorrentino, Gabriella Sozzi, Silvano Ferrini, Sandra Rosini, Giulia Bertolini, Mauro Truini, Francesco Grossi, Luis Juan Vicente Galietta, Domenico Ribatti, Vito Pistoia |
| Abstract |
Non small cell lung cancer (NSCLC) is a leading cause of cancer death. We have shown previously that IL-12rb2 KO mice develop spontaneously lung adenocarcinomas or bronchioalveolar carcinomas. Aim of the study was to investigate i) IL-12Rbeta2 expression in human primary lung adenocarcinomas and in their counterparts, i.e. normal bronchial epithelial cells (NBEC), ii) the direct anti-tumor activity of IL-12 on lung adenocarcinoma cells in vitro and vivo, and the mechanisms involved, and iii) IL-12 activity on NBEC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 3% |
| Italy | 1 | 3% |
| Unknown | 30 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 16% |
| Student > Ph. D. Student | 4 | 13% |
| Student > Master | 4 | 13% |
| Other | 3 | 9% |
| Professor | 3 | 9% |
| Other | 5 | 16% |
| Unknown | 8 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 25% |
| Agricultural and Biological Sciences | 7 | 22% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Immunology and Microbiology | 2 | 6% |
| Sports and Recreations | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 31% |