| Title |
Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis
|
|---|---|
| Published in |
PLOS ONE, June 2009
|
| DOI | 10.1371/journal.pone.0006073 |
| Pubmed ID | |
| Authors |
Yutao Yan, Vasantha Kolachala, Guillaume Dalmasso, Hang Nguyen, Hamed Laroui, Shanthi V. Sitaraman, Didier Merlin |
| Abstract |
Inflammatory bowel diseases (IBD), including mainly ulcerative colitis (UC) and Crohn's disease (CD), are inflammatory disorders of the gastrointestinal tract caused by an interplay of genetic and environmental factors. Murine colitis model induced by Dextran Sulfate Sodium (DSS) is an animal model of IBD that is commonly used to address the pathogenesis of IBD as well as to test efficacy of therapies. In this study we systematically analyzed clinical parameters, histological changes, intestinal barrier properties and cytokine profile during the colitic and recovery phase. |
Mendeley readers
The data shown below were compiled from readership statistics for 326 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Spain | 2 | <1% |
| Germany | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Ireland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 316 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 24% |
| Researcher | 52 | 16% |
| Student > Master | 37 | 11% |
| Student > Bachelor | 27 | 8% |
| Student > Doctoral Student | 21 | 6% |
| Other | 44 | 13% |
| Unknown | 68 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 26% |
| Biochemistry, Genetics and Molecular Biology | 41 | 13% |
| Medicine and Dentistry | 40 | 12% |
| Immunology and Microbiology | 38 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
| Other | 32 | 10% |
| Unknown | 79 | 24% |