| Title |
The Timing of the Shrew: Continuous Melatonin Treatment Maintains Youthful Rhythmic Activity in Aging Crocidura russula
|
|---|---|
| Published in |
PLOS ONE, June 2009
|
| DOI | 10.1371/journal.pone.0005904 |
| Pubmed ID | |
| Authors |
Elodie Magnanou, Joël Attia, Roger Fons, Gilles Boeuf, Jack Falcon |
| Abstract |
Laboratory conditions nullify the extrinsic factors that determine the wild expected lifespan and release the intrinsic or potential lifespan. Thus, wild animals reared in a laboratory often show an increased lifespan, and consequently an increased senescence phase. Senescence is associated with a broad suite of physiological changes, including a decreased responsiveness of the circadian system. The time-keeping hormone melatonin, an important chemical player in this system, is suspected to have an anti-aging role. The Greater White-toothed shrew Crocidura russula is an ideal study model to address questions related to aging and associated changes in biological functions: its lifespan is short and is substantially increased in captivity; daily and seasonal rhythms, while very marked the first year of life, are dramatically altered during the senescence process which starts during the second year. Here we report on an investigation of the effects of melatonin administration on locomotor activity of aging shrews. |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 4% |
| Netherlands | 1 | 4% |
| France | 1 | 4% |
| Switzerland | 1 | 4% |
| Unknown | 20 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 29% |
| Student > Ph. D. Student | 6 | 25% |
| Professor > Associate Professor | 3 | 13% |
| Student > Master | 3 | 13% |
| Other | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 2 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 67% |
| Environmental Science | 1 | 4% |
| Linguistics | 1 | 4% |
| Psychology | 1 | 4% |
| Materials Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 3 | 13% |