Title |
Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
|
---|---|
Published in |
PLOS ONE, May 2009
|
DOI | 10.1371/journal.pone.0005741 |
Pubmed ID | |
Authors |
Benjamin R. Myers, Yaron M. Sigal, David Julius |
Abstract |
Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 2% |
Portugal | 1 | <1% |
South Africa | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
Unknown | 99 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 28% |
Researcher | 13 | 12% |
Professor > Associate Professor | 13 | 12% |
Student > Bachelor | 10 | 10% |
Student > Master | 8 | 8% |
Other | 18 | 17% |
Unknown | 14 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 60 | 57% |
Biochemistry, Genetics and Molecular Biology | 13 | 12% |
Neuroscience | 8 | 8% |
Veterinary Science and Veterinary Medicine | 3 | 3% |
Chemistry | 2 | 2% |
Other | 6 | 6% |
Unknown | 13 | 12% |