| Title |
Systemic Inhibition of NF-κB Activation Protects from Silicosis
|
|---|---|
| Published in |
PLOS ONE, May 2009
|
| DOI | 10.1371/journal.pone.0005689 |
| Pubmed ID | |
| Authors |
Michelangelo Di Giuseppe, Federica Gambelli, Gary W. Hoyle, Giuseppe Lungarella, Sean M. Studer, Thomas Richards, Sam Yousem, Ken McCurry, James Dauber, Naftali Kaminski, George Leikauf, Luis A. Ortiz |
| Abstract |
Silicosis is a complex lung disease for which no successful treatment is available and therefore lung transplantation is a potential alternative. Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathogenesis of silicosis. TNFalpha signaling is mediated by the transcription factor, Nuclear Factor (NF)-kappaB, which regulates genes controlling several physiological processes including the innate immune responses, cell death, and inflammation. Therefore, inhibition of NF-kappaB activation represents a potential therapeutic strategy for silicosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 18% |
| Student > Master | 6 | 12% |
| Researcher | 5 | 10% |
| Professor > Associate Professor | 5 | 10% |
| Student > Ph. D. Student | 5 | 10% |
| Other | 13 | 26% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 26% |
| Medicine and Dentistry | 12 | 24% |
| Immunology and Microbiology | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 12 | 24% |