Title |
Serotonylation of Vascular Proteins Important to Contraction
|
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Published in |
PLOS ONE, May 2009
|
DOI | 10.1371/journal.pone.0005682 |
Pubmed ID | |
Authors |
Stephanie W. Watts, Jessica R. C. Priestley, Janice M. Thompson |
Abstract |
Serotonin (5-hydroxytryptamine, 5-HT) was named for its source (sero-) and ability to modify smooth muscle tone (tonin). The biological effects of 5-HT are believed to be carried out by stimulation of serotonin receptors at the plasma membrane. Serotonin has recently been shown to be synthesized in vascular smooth muscle and taken up from external sources, placing 5-HT inside the cell. The enzyme transglutaminase uses primary amines such as 5-HT to covalently modify proteins on glutamine residues. We tested the hypothesis that 5-HT is a substrate for transglutaminase in arterial vascular smooth muscle, with protein serotonylation having physiological function. |
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Demographic breakdown
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