| Title |
Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons
|
|---|---|
| Published in |
PLOS ONE, April 2009
|
| DOI | 10.1371/journal.pone.0005390 |
| Pubmed ID | |
| Authors |
Luc Dupuis, Jose-Luis Gonzalez de Aguilar, Andoni Echaniz-Laguna, Judith Eschbach, Frédérique Rene, Hugues Oudart, Benoit Halter, Caroline Huze, Laurent Schaeffer, Frédéric Bouillaud, Jean-Philippe Loeffler |
| Abstract |
Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron disease, is associated with hypermetabolism linked to defects in muscle mitochondrial energy metabolism such as ATP depletion and increased oxygen consumption. It remains unknown whether muscle abnormalities in energy metabolism are causally involved in the destruction of neuromuscular junction (NMJ) and subsequent motor neuron degeneration during ALS. |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Uruguay | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 176 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 22% |
| Researcher | 39 | 21% |
| Student > Master | 19 | 10% |
| Student > Bachelor | 15 | 8% |
| Professor > Associate Professor | 11 | 6% |
| Other | 27 | 15% |
| Unknown | 31 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 31% |
| Biochemistry, Genetics and Molecular Biology | 33 | 18% |
| Neuroscience | 21 | 11% |
| Medicine and Dentistry | 13 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 19 | 10% |
| Unknown | 38 | 21% |