Title |
Conservation of Carbohydrate Binding Interfaces — Evidence of Human HBGA Selection in Norovirus Evolution
|
---|---|
Published in |
PLOS ONE, April 2009
|
DOI | 10.1371/journal.pone.0005058 |
Pubmed ID | |
Authors |
Ming Tan, Ming Xia, Yutao Chen, Weiming Bu, Rashmi S. Hegde, Jarek Meller, Xuemei Li, Xi Jiang |
Abstract |
Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two major genogroups (GI and GII) and approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recently the crystal structures of the HBGA-binding interfaces of the GI Norwalk virus and the GII VA387 have been determined, which allows us to examine the genetic and structural relationships of the HBGA-binding interfaces of noroviruses with variable HBGA-binding patterns. Our hypothesis is that, if HBGAs are the viral receptors necessary for norovirus infection and spread, their binding interfaces should be under a selection pressure in the evolution of noroviruses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 2% |
Brazil | 1 | 1% |
United Kingdom | 1 | 1% |
Ukraine | 1 | 1% |
Peru | 1 | 1% |
Afghanistan | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Poland | 1 | 1% |
Other | 0 | 0% |
Unknown | 75 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 21% |
Researcher | 18 | 21% |
Student > Master | 11 | 13% |
Student > Bachelor | 10 | 12% |
Professor | 6 | 7% |
Other | 12 | 14% |
Unknown | 10 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 44% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Medicine and Dentistry | 7 | 8% |
Immunology and Microbiology | 4 | 5% |
Environmental Science | 3 | 4% |
Other | 9 | 11% |
Unknown | 13 | 15% |