Title |
High-Fat Diet Induces Apoptosis of Hypothalamic Neurons
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Published in |
PLOS ONE, April 2009
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DOI | 10.1371/journal.pone.0005045 |
Pubmed ID | |
Authors |
Juliana C. Moraes, Andressa Coope, Joseane Morari, Dennys E. Cintra, Erika A. Roman, José R. Pauli, Talita Romanatto, José B. Carvalheira, Alexandre L. R. Oliveira, Mario J. Saad, Licio A. Velloso |
Abstract |
Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammatory signal transduction can lead to the activation of apoptotic signaling pathways, we evaluated the effect of high-fat feeding on the induction of apoptosis of hypothalamic cells. Here, we show that consumption of dietary fats induce apoptosis of neurons and a reduction of synaptic inputs in the arcuate nucleus and lateral hypothalamus. This effect is dependent upon diet composition, and not on caloric intake, since pair-feeding is not sufficient to reduce the expression of apoptotic markers. The presence of an intact TLR4 receptor, protects cells from further apoptotic signals. In diet-induced inflammation of the hypothalamus, TLR4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 1% |
Spain | 3 | <1% |
Brazil | 2 | <1% |
Canada | 2 | <1% |
France | 1 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 355 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 74 | 20% |
Student > Master | 52 | 14% |
Student > Bachelor | 52 | 14% |
Researcher | 45 | 12% |
Student > Doctoral Student | 27 | 7% |
Other | 55 | 15% |
Unknown | 65 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 91 | 25% |
Neuroscience | 63 | 17% |
Biochemistry, Genetics and Molecular Biology | 55 | 15% |
Medicine and Dentistry | 45 | 12% |
Nursing and Health Professions | 6 | 2% |
Other | 31 | 8% |
Unknown | 79 | 21% |