| Title |
Where Does Mediator Bind In Vivo?
|
|---|---|
| Published in |
PLOS ONE, April 2009
|
| DOI | 10.1371/journal.pone.0005029 |
| Pubmed ID | |
| Authors |
Xiaochun Fan, Kevin Struhl |
| Abstract |
The Mediator complex associates with RNA polymerase (Pol) II, and it is recruited to enhancer regions by activator proteins under appropriate environmental conditions. However, the issue of Mediator association in yeast cells is controversial. Under optimal growth conditions (YPD medium), we were unable to detect Mediator at essentially any S. cerevisiae promoter region, including those supporting very high levels of transcription. In contrast, whole genome microarray experiments in synthetic complete (SC) medium reported that Mediator associates with many genes at both promoter and coding regions. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 4% |
| United States | 2 | 3% |
| Ireland | 1 | 1% |
| New Zealand | 1 | 1% |
| Unknown | 67 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 32% |
| Researcher | 15 | 20% |
| Professor > Associate Professor | 7 | 9% |
| Professor | 6 | 8% |
| Student > Master | 5 | 7% |
| Other | 9 | 12% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 53% |
| Biochemistry, Genetics and Molecular Biology | 20 | 27% |
| Immunology and Microbiology | 2 | 3% |
| Social Sciences | 2 | 3% |
| Linguistics | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 7 | 9% |