| Title |
Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis
|
|---|---|
| Published in |
PLOS ONE, March 2009
|
| DOI | 10.1371/journal.pone.0004952 |
| Pubmed ID | |
| Authors |
Sergey A. Shiryaev, Alexei Y. Savinov, Piotr Cieplak, Boris I. Ratnikov, Khatereh Motamedchaboki, Jeffrey W. Smith, Alex Y. Strongin |
| Abstract |
Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms are predominantly expressed in the oligodendrocytes of the CNS. The splice variants of the single MBP gene (Golli-MBP BG21 and J37) are widely expressed in the neurons and also in the immune cells. The relative contribution of the individual MMPs to the MBP cleavage is not known. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Finland | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 69 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Researcher | 11 | 15% |
| Student > Bachelor | 9 | 12% |
| Student > Master | 7 | 9% |
| Professor > Associate Professor | 5 | 7% |
| Other | 16 | 22% |
| Unknown | 15 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 22% |
| Medicine and Dentistry | 12 | 16% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Neuroscience | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 19 | 26% |