| Title |
Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression
|
|---|---|
| Published in |
PLOS ONE, March 2009
|
| DOI | 10.1371/journal.pone.0004832 |
| Pubmed ID | |
| Authors |
Jon A. Oyer, Adrian Chu, Sukhmani Brar, Mitchell S. Turker |
| Abstract |
Aberrant epigenetic silencing plays a major role in cancer formation by inactivating tumor suppressor genes. While the endpoints of aberrant silencing are known, i.e., promoter region DNA methylation and altered histone modifications, the triggers of silencing are not known. We used the tet-off system to test the hypothesis that a transient reduction in gene expression will sensitize a promoter to undergo epigenetic silencing. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 29% |
| Researcher | 9 | 20% |
| Student > Bachelor | 4 | 9% |
| Professor | 3 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 16% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 36% |
| Biochemistry, Genetics and Molecular Biology | 10 | 22% |
| Medicine and Dentistry | 3 | 7% |
| Neuroscience | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 9 | 20% |