Title |
Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
|
---|---|
Published in |
PLOS ONE, February 2009
|
DOI | 10.1371/journal.pone.0004606 |
Pubmed ID | |
Authors |
Fayçal Guedj, Catherine Sébrié, Isabelle Rivals, Aurelie Ledru, Evelyne Paly, Jean C. Bizot, Desmond Smith, Edward Rubin, Brigitte Gillet, Mariona Arbones, Jean M. Delabar |
Abstract |
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 172 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 22% |
Student > Ph. D. Student | 34 | 19% |
Student > Bachelor | 29 | 16% |
Student > Master | 17 | 9% |
Student > Doctoral Student | 9 | 5% |
Other | 30 | 17% |
Unknown | 21 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 24% |
Medicine and Dentistry | 30 | 17% |
Biochemistry, Genetics and Molecular Biology | 21 | 12% |
Neuroscience | 18 | 10% |
Psychology | 10 | 6% |
Other | 27 | 15% |
Unknown | 30 | 17% |