| Title |
Expression of Activated PIK3CA in Ovarian Surface Epithelium Results in Hyperplasia but Not Tumor Formation
|
|---|---|
| Published in |
PLOS ONE, January 2009
|
| DOI | 10.1371/journal.pone.0004295 |
| Pubmed ID | |
| Authors |
Shun Liang, Nuo Yang, Yue Pan, Shan Deng, Xiaojuan Lin, Xiaojun Yang, Dionyssios Katsaros, Katherine F. Roby, Thomas C. Hamilton, Denise C. Connolly, George Coukos, Lin Zhang |
| Abstract |
The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE) is largely unclear. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 2% |
| Japan | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 28% |
| Student > Ph. D. Student | 8 | 14% |
| Researcher | 8 | 14% |
| Student > Master | 5 | 9% |
| Student > Doctoral Student | 2 | 3% |
| Other | 10 | 17% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 29% |
| Agricultural and Biological Sciences | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Engineering | 3 | 5% |
| Immunology and Microbiology | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 9 | 16% |