| Title |
Modulation of Macrophage Activation State Protects Tissue from Necrosis during Critical Limb Ischemia in Thrombospondin-1-Deficient Mice
|
|---|---|
| Published in |
PLOS ONE, December 2008
|
| DOI | 10.1371/journal.pone.0003950 |
| Pubmed ID | |
| Authors |
Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Michael Dussiot, Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-Sébastien Silvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud, Stéphane Germain |
| Abstract |
Macrophages, key regulators of healing/regeneration processes, strongly infiltrate ischemic tissues from patients suffering from critical limb ischemia (CLI). However pro-inflammatory markers correlate with disease progression and risk of amputation, suggesting that modulating macrophage activation state might be beneficial. We previously reported that thrombospondin-1 (TSP-1) is highly expressed in ischemic tissues during CLI in humans. TSP-1 is a matricellular protein that displays well-known angiostatic properties in cancer, and regulates inflammation in vivo and macrophages properties in vitro. We therefore sought to investigate its function in a mouse model of CLI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 5% |
| Austria | 1 | 1% |
| Germany | 1 | 1% |
| Spain | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 66 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 28% |
| Student > Ph. D. Student | 18 | 24% |
| Professor > Associate Professor | 8 | 11% |
| Student > Master | 7 | 9% |
| Professor | 4 | 5% |
| Other | 10 | 14% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 42% |
| Medicine and Dentistry | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Engineering | 4 | 5% |
| Neuroscience | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 11 | 15% |