| Title |
Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells
|
|---|---|
| Published in |
PLOS ONE, December 2008
|
| DOI | 10.1371/journal.pone.0003942 |
| Pubmed ID | |
| Authors |
Mark Throsby, Edward van den Brink, Mandy Jongeneelen, Leo L. M. Poon, Philippe Alard, Lisette Cornelissen, Arjen Bakker, Freek Cox, Els van Deventer, Yi Guan, Jindrich Cinatl, Jan ter Meulen, Ignace Lasters, Rita Carsetti, Malik Peiris, John de Kruif, Jaap Goudsmit |
| Abstract |
The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses only provide efficient protection against a narrow spectrum of HA antigenic variants within a given virus subtype. Avian influenza viruses such as H5N1 are currently panzootic and pose a pandemic threat. These viruses are antigenically diverse and protective strategies need to cross protect against diverse viral clades. Furthermore, there are 16 different HA subtypes and no certainty the next pandemic will be caused by an H5 subtype, thus it is important to develop prophylactic and therapeutic interventions that provide heterosubtypic protection. |
Mendeley readers
The data shown below were compiled from readership statistics for 341 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Brazil | 2 | <1% |
| Netherlands | 1 | <1% |
| Indonesia | 1 | <1% |
| Taiwan | 1 | <1% |
| Mexico | 1 | <1% |
| Italy | 1 | <1% |
| Denmark | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 324 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 88 | 26% |
| Researcher | 86 | 25% |
| Student > Master | 27 | 8% |
| Student > Bachelor | 27 | 8% |
| Other | 13 | 4% |
| Other | 44 | 13% |
| Unknown | 56 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 115 | 34% |
| Biochemistry, Genetics and Molecular Biology | 46 | 13% |
| Immunology and Microbiology | 45 | 13% |
| Medicine and Dentistry | 28 | 8% |
| Engineering | 9 | 3% |
| Other | 31 | 9% |
| Unknown | 67 | 20% |