Title |
VHL Type 2B Mutations Retain VBC Complex Form and Function
|
---|---|
Published in |
PLOS ONE, November 2008
|
DOI | 10.1371/journal.pone.0003801 |
Pubmed ID | |
Authors |
Kathryn E. Hacker, Caroline Martz Lee, W. Kimryn Rathmell |
Abstract |
von Hippel-Lindau disease is characterized by a spectrum of hypervascular tumors, including renal cell carcinoma, hemangioblastoma, and pheochromocytoma, which occur with VHL genotype-specific differences in penetrance. VHL loss causes a failure to regulate the hypoxia inducible factors (HIF-1alpha and HIF-2alpha), resulting in accumulation of both factors to high levels. Although HIF dysregulation is critical to VHL disease-associated renal tumorigenesis, increasing evidence points toward gradations of HIF dysregulation contributing to the degree of predisposition to renal cell carcinoma and other manifestations of the disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 29% |
Other | 4 | 19% |
Researcher | 4 | 19% |
Student > Postgraduate | 2 | 10% |
Student > Bachelor | 1 | 5% |
Other | 3 | 14% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 38% |
Medicine and Dentistry | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Neuroscience | 1 | 5% |
Unspecified | 1 | 5% |
Other | 0 | 0% |
Unknown | 3 | 14% |