Title |
Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients
|
---|---|
Published in |
PLOS ONE, November 2008
|
DOI | 10.1371/journal.pone.0003799 |
Pubmed ID | |
Authors |
Eric A. Moulton, Rami Burstein, Shannon Tully, Richard Hargreaves, Lino Becerra, David Borsook |
Abstract |
The brainstem contains descending circuitry that can modulate nociceptive processing (neural signals associated with pain) in the dorsal horn of the spinal cord and the medullary dorsal horn. In migraineurs, abnormal brainstem function during attacks suggest that dysfunction of descending modulation may facilitate migraine attacks, either by reducing descending inhibition or increasing facilitation. To determine whether a brainstem dysfunction could play a role in facilitating migraine attacks, we measured brainstem function in migraineurs when they were not having an attack (i.e. the interictal phase). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 5 | 4% |
Brazil | 3 | 2% |
United States | 3 | 2% |
United Kingdom | 2 | 1% |
Unknown | 124 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 35 | 26% |
Student > Ph. D. Student | 19 | 14% |
Student > Master | 13 | 9% |
Student > Bachelor | 13 | 9% |
Professor | 7 | 5% |
Other | 27 | 20% |
Unknown | 23 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 36% |
Neuroscience | 24 | 18% |
Agricultural and Biological Sciences | 11 | 8% |
Psychology | 7 | 5% |
Nursing and Health Professions | 3 | 2% |
Other | 9 | 7% |
Unknown | 34 | 25% |