| Title |
FRET Imaging of Hemoglobin Concentration in Plasmodium falciparum-Infected Red Cells
|
|---|---|
| Published in |
PLOS ONE, November 2008
|
| DOI | 10.1371/journal.pone.0003780 |
| Pubmed ID | |
| Authors |
Alessandro Esposito, Teresa Tiffert, Jakob M. A. Mauritz, Simon Schlachter, Lawrence H. Bannister, Clemens F. Kaminski, Virgilio L. Lew |
| Abstract |
During its intraerythrocytic asexual reproduction cycle Plasmodium falciparum consumes up to 80% of the host cell hemoglobin, in large excess over its metabolic needs. A model of the homeostasis of falciparum-infected red blood cells suggested an explanation based on the need to reduce the colloid-osmotic pressure within the host cell to prevent its premature lysis. Critical for this hypothesis was that the hemoglobin concentration within the host cell be progressively reduced from the trophozoite stage onwards. |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Brazil | 1 | 1% |
| India | 1 | 1% |
| Finland | 1 | 1% |
| Korea, Republic of | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 85 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 26% |
| Researcher | 20 | 22% |
| Student > Master | 11 | 12% |
| Student > Doctoral Student | 5 | 5% |
| Professor > Associate Professor | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 13 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 35% |
| Chemistry | 9 | 10% |
| Physics and Astronomy | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Engineering | 7 | 8% |
| Other | 13 | 14% |
| Unknown | 15 | 16% |