Title |
APC Activation Restores Functional CD4+CD25+ Regulatory T Cells in NOD Mice that Can Prevent Diabetes Development
|
---|---|
Published in |
PLOS ONE, November 2008
|
DOI | 10.1371/journal.pone.0003739 |
Pubmed ID | |
Authors |
Jean N. Manirarora, Michele M. Kosiewicz, Sarah A. Parnell, Pascale Alard |
Abstract |
Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure of NOD APC to properly activate CD4(+)CD25(+) regulatory cells in vivo could compromise their ability to control pathogenic cells, and activation of NOD APC could restore this defect, thereby preventing disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 21% |
Researcher | 4 | 21% |
Student > Doctoral Student | 2 | 11% |
Student > Bachelor | 1 | 5% |
Student > Master | 1 | 5% |
Other | 3 | 16% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 47% |
Medicine and Dentistry | 5 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Arts and Humanities | 1 | 5% |
Unknown | 3 | 16% |