Title |
Opposite Effects of Early Maternal Deprivation on Neurogenesis in Male versus Female Rats
|
---|---|
Published in |
PLOS ONE, January 2009
|
DOI | 10.1371/journal.pone.0003675 |
Pubmed ID | |
Authors |
Charlotte A. Oomen, Carlos E. N. Girardi, Rudy Cahyadi, Eva C. Verbeek, Harm Krugers, Marian Joëls, Paul J. Lucassen |
Abstract |
Major depression is more prevalent in women than in men. The underlying neurobiological mechanisms are not well understood, but recent data shows that hippocampal volume reductions in depressed women occur only when depression is preceded by an early life stressor. This underlines the potential importance of early life stress, at least in women, for the vulnerability to develop depression. Perinatal stress exposure in rodents affects critical periods of brain development that persistently alter structural, emotional and neuroendocrine parameters in adult offspring. Moreover, stress inhibits adult hippocampal neurogenesis, a form of structural plasticity that has been implicated a.o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | <1% |
Canada | 2 | <1% |
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
France | 1 | <1% |
Mexico | 1 | <1% |
New Zealand | 1 | <1% |
Other | 2 | <1% |
Unknown | 209 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 49 | 22% |
Student > Bachelor | 35 | 16% |
Student > Master | 30 | 13% |
Researcher | 29 | 13% |
Professor > Associate Professor | 17 | 8% |
Other | 35 | 16% |
Unknown | 28 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 65 | 29% |
Agricultural and Biological Sciences | 60 | 27% |
Psychology | 22 | 10% |
Medicine and Dentistry | 17 | 8% |
Biochemistry, Genetics and Molecular Biology | 7 | 3% |
Other | 10 | 4% |
Unknown | 42 | 19% |