| Title |
Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study
|
|---|---|
| Published in |
PLOS ONE, November 2008
|
| DOI | 10.1371/journal.pone.0003637 |
| Pubmed ID | |
| Authors |
Luc Letenneur, Karine Pérès, Hervé Fleury, Isabelle Garrigue, Pascale Barberger-Gateau, Catherine Helmer, Jean-Marc Orgogozo, Serge Gauthier, Jean-François Dartigues |
| Abstract |
Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer's Disease (AD) notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the disease. We investigated the risk of developing AD in anti-HSV immunoglobulin G (IgG) positive subjects (indicator of a lifelong infection to HSV) and IgM-positive subjects (indicator of primary infection or reactivation of the virus) in a longitudinal population-based cohort of elderly subjects living in the community. |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Greece | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 155 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 15% |
| Student > Ph. D. Student | 22 | 14% |
| Student > Bachelor | 22 | 14% |
| Student > Master | 18 | 11% |
| Student > Doctoral Student | 8 | 5% |
| Other | 28 | 18% |
| Unknown | 37 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 20% |
| Agricultural and Biological Sciences | 21 | 13% |
| Biochemistry, Genetics and Molecular Biology | 17 | 11% |
| Neuroscience | 12 | 8% |
| Immunology and Microbiology | 11 | 7% |
| Other | 24 | 15% |
| Unknown | 42 | 26% |