Title |
ES-Cell Derived Hematopoietic Cells Induce Transplantation Tolerance
|
---|---|
Published in |
PLOS ONE, September 2008
|
DOI | 10.1371/journal.pone.0003212 |
Pubmed ID | |
Authors |
Sabrina Bonde, Kun-Ming Chan, Nicholas Zavazava |
Abstract |
Bone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance. However, their strong immunogenicity precludes routine use in clinical transplantation due to the need for harsh preconditioning and the requirement for toxic immunosuppression to prevent rejection and graft-versus-host disease. Alternatively, embryonic stem (ES) cells have emerged as a potential source of less immunogenic hematopoietic progenitor cells (HPCs). Up till now, however, it has been difficult to generate stable hematopoietic cells from ES cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 5% |
United States | 2 | 5% |
Unknown | 38 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 26% |
Researcher | 9 | 21% |
Professor > Associate Professor | 5 | 12% |
Other | 3 | 7% |
Student > Master | 3 | 7% |
Other | 7 | 17% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 26% |
Medicine and Dentistry | 9 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Engineering | 4 | 10% |
Immunology and Microbiology | 3 | 7% |
Other | 4 | 10% |
Unknown | 6 | 14% |