Title |
A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos
|
---|---|
Published in |
PLOS ONE, August 2008
|
DOI | 10.1371/journal.pone.0002919 |
Pubmed ID | |
Authors |
Arach Goldar, Hélène Labit, Kathrin Marheineke, Olivier Hyrien |
Abstract |
Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time. This is an acute problem in early Xenopus embryos since DNA replication origins are located and activated stochastically, leading to the random completion problem. DNA combing, kinetic modelling and other studies using Xenopus egg extracts have suggested that potential origins are much more abundant than actual initiation events and that the time-dependent rate of initiation, I(t), markedly increases through S phase to ensure the rapid completion of unreplicated gaps and a narrow distribution of completion times. However, the molecular mechanism that underlies this increase has remained obscure. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 6% |
Poland | 1 | 3% |
France | 1 | 3% |
Unknown | 31 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 34% |
Researcher | 9 | 26% |
Student > Master | 4 | 11% |
Professor > Associate Professor | 3 | 9% |
Professor | 1 | 3% |
Other | 3 | 9% |
Unknown | 3 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 54% |
Physics and Astronomy | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Engineering | 3 | 9% |
Computer Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 3 | 9% |