| Title |
Mdm2 Induces Mono-Ubiquitination of FOXO4
|
|---|---|
| Published in |
PLOS ONE, July 2008
|
| DOI | 10.1371/journal.pone.0002819 |
| Pubmed ID | |
| Authors |
Arjan B. Brenkman, Peter L. J. de Keizer, Niels J. F. van den Broek, A. G. Jochemsen, Boudewijn M. Burgering |
| Abstract |
The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 are remarkably similar within their spectrum of regulatory proteins. For example, the de-ubiquitinating enzyme USP7 removes ubiquitin from both FOXO and p53. However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 84 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 26% |
| Student > Ph. D. Student | 17 | 20% |
| Student > Master | 12 | 14% |
| Professor > Associate Professor | 7 | 8% |
| Student > Bachelor | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 11 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 40% |
| Biochemistry, Genetics and Molecular Biology | 28 | 33% |
| Medicine and Dentistry | 6 | 7% |
| Immunology and Microbiology | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 12 | 14% |