| Title |
AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand
|
|---|---|
| Published in |
PLOS ONE, July 2008
|
| DOI | 10.1371/journal.pone.0002735 |
| Pubmed ID | |
| Authors |
Patricia Chastagner, Alain Israël, Christel Brou |
| Abstract |
The regulation of Notch signaling heavily relies on ubiquitination events. Drosophila Su(dx), a member of the HECT family of ubiquitin-ligases, has been described as a negative regulator of Notch signaling, acting on the post-endocytic sorting of Notch. The mammalian ortholog of Su(dx), Itch/AIP4, has been shown to have multiple substrates, including Notch, but the precise events regulated by Itch/AIP4 in the Notch pathway have not been identified yet. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 88 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 38% |
| Researcher | 14 | 16% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 6 | 7% |
| Student > Master | 4 | 4% |
| Other | 9 | 10% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 44% |
| Biochemistry, Genetics and Molecular Biology | 25 | 28% |
| Medicine and Dentistry | 4 | 4% |
| Immunology and Microbiology | 2 | 2% |
| Arts and Humanities | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 15 | 17% |