| Title |
Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells
|
|---|---|
| Published in |
PLOS ONE, June 2008
|
| DOI | 10.1371/journal.pone.0002528 |
| Pubmed ID | |
| Authors |
Sabrina Rotolo, Simona Ceccarelli, Ferdinando Romano, Luigi Frati, Cinzia Marchese, Antonio Angeloni |
| Abstract |
Keratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers. |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 4 | 20% |
| Researcher | 4 | 20% |
| Student > Master | 3 | 15% |
| Student > Ph. D. Student | 2 | 10% |
| Professor > Associate Professor | 2 | 10% |
| Other | 3 | 15% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 35% |
| Medicine and Dentistry | 5 | 25% |
| Psychology | 2 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Chemistry | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 2 | 10% |