| Title |
Dopamine Agonist Increases Risk Taking but Blunts Reward-Related Brain Activity
|
|---|---|
| Published in |
PLOS ONE, June 2008
|
| DOI | 10.1371/journal.pone.0002479 |
| Pubmed ID | |
| Authors |
Jordi Riba, Ulrike M. Krämer, Marcus Heldmann, Sylvia Richter, Thomas F. Münte |
| Abstract |
The use of D2/D3 dopaminergic agonists in Parkinson's disease (PD) may lead to pathological gambling. In a placebo-controlled double-blind study in healthy volunteers, we observed riskier choices in a lottery task after administration of the D3 receptor-preferring agonist pramipexole thus mimicking risk-taking behavior in PD. Moreover, we demonstrate decreased activation in the rostral basal ganglia and midbrain, key structures of the reward system, following unexpected high gains and therefore propose that pathological gambling in PD results from the need to seek higher rewards to overcome the blunted response in this system. |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 3 | 2% |
| United States | 3 | 2% |
| United Kingdom | 3 | 2% |
| Italy | 2 | 1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Russia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 147 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 19% |
| Student > Ph. D. Student | 28 | 17% |
| Student > Master | 19 | 12% |
| Student > Doctoral Student | 12 | 7% |
| Professor | 11 | 7% |
| Other | 40 | 25% |
| Unknown | 21 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 41 | 25% |
| Agricultural and Biological Sciences | 24 | 15% |
| Neuroscience | 22 | 14% |
| Medicine and Dentistry | 20 | 12% |
| Economics, Econometrics and Finance | 4 | 2% |
| Other | 21 | 13% |
| Unknown | 30 | 19% |