Title |
Mast Cell-Derived Histamine Mediates Cystitis Pain
|
---|---|
Published in |
PLOS ONE, May 2008
|
DOI | 10.1371/journal.pone.0002096 |
Pubmed ID | |
Authors |
Charles N. Rudick, Paul J. Bryce, Laura A. Guichelaar, Ruth E. Berry, David J. Klumpp |
Abstract |
Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC) is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent inflammation, but IC symptoms correlate with elevated bladder lamina propria mast cell counts. We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Ireland | 1 | 1% |
Unknown | 68 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 21% |
Student > Bachelor | 13 | 18% |
Student > Ph. D. Student | 11 | 15% |
Other | 6 | 8% |
Student > Master | 6 | 8% |
Other | 12 | 17% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 24% |
Agricultural and Biological Sciences | 16 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Chemistry | 4 | 6% |
Other | 11 | 15% |
Unknown | 14 | 20% |