| Title |
Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex
|
|---|---|
| Published in |
PLOS ONE, April 2008
|
| DOI | 10.1371/journal.pone.0002040 |
| Pubmed ID | |
| Authors |
Adinda Wellens, Corinne Garofalo, Hien Nguyen, Nani Van Gerven, Rikard Slättegård, Jean-Pierre Hernalsteens, Lode Wyns, Stefan Oscarson, Henri De Greve, Scott Hultgren, Julie Bouckaert |
| Abstract |
Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably via pathways mediated by the high-mannosylated uroplakin-Ia and alpha3beta1 integrins found throughout the uroepithelium. Invaded bacteria replicate and mature into dense, biofilm-like inclusions in preparation of fluxing and of infection of neighbouring cells, being the major cause of the troublesome recurrent urinary tract infections. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Nigeria | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 159 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 22% |
| Researcher | 33 | 20% |
| Student > Bachelor | 14 | 8% |
| Student > Master | 11 | 7% |
| Professor | 10 | 6% |
| Other | 29 | 17% |
| Unknown | 34 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 27% |
| Chemistry | 18 | 11% |
| Medicine and Dentistry | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 14 | 8% |
| Immunology and Microbiology | 13 | 8% |
| Other | 19 | 11% |
| Unknown | 43 | 26% |