Title |
Orexigenic Hormone Ghrelin Attenuates Local and Remote Organ Injury after Intestinal Ischemia-Reperfusion
|
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Published in |
PLOS ONE, April 2008
|
DOI | 10.1371/journal.pone.0002026 |
Pubmed ID | |
Authors |
Rongqian Wu, Weifeng Dong, Youxin Ji, Mian Zhou, Corrado P. Marini, Thanjavur S. Ravikumar, Ping Wang |
Abstract |
Gut ischemia/reperfusion (I/R) injury is a serious condition in intensive care patients. Activation of immune cells adjacent to the huge endothelial cell surface area of the intestinal microvasculature produces initially local and then systemic inflammatory responses. Stimulation of the vagus nerve can rapidly attenuate systemic inflammatory responses through inhibiting the activation of macrophages and endothelial cells. Ghrelin, a novel orexigenic hormone, is produced predominately in the gastrointestinal system. Ghrelin receptors are expressed at a high density in the dorsal vagal complex of the brain stem. In this study, we investigated the regulation of the cholinergic anti-inflammatory pathway by the novel gastrointestinal hormone, ghrelin, after gut I/R. |
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Demographic breakdown
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