| Title |
Functional Significance of Allelic Variation at methuselah, an Aging Gene in Drosophila
|
|---|---|
| Published in |
PLOS ONE, April 2008
|
| DOI | 10.1371/journal.pone.0001987 |
| Pubmed ID | |
| Authors |
Annalise B. Paaby, Paul S. Schmidt |
| Abstract |
Longevity and age-specific patterns of mortality are complex traits that vary within and among taxa. Multiple candidate genes for aging have been identified in model systems by extended longevity mutant phenotypes, including the G-protein coupled receptor methuselah (mth) in D. melanogaster. These genes offer important insights into the mechanisms of lifespan determination and have been major targets of interest in the biology of aging. However, it is largely unknown whether these genes contribute to genetic variance for lifespan in natural populations, and consequently contribute to lifespan evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 7% |
| Switzerland | 2 | 3% |
| United Kingdom | 2 | 3% |
| South Africa | 1 | 2% |
| India | 1 | 2% |
| Spain | 1 | 2% |
| Romania | 1 | 2% |
| Unknown | 48 | 80% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 27% |
| Researcher | 16 | 27% |
| Student > Master | 5 | 8% |
| Student > Bachelor | 4 | 7% |
| Other | 4 | 7% |
| Other | 9 | 15% |
| Unknown | 6 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 63% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Medicine and Dentistry | 3 | 5% |
| Earth and Planetary Sciences | 1 | 2% |
| Environmental Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 6 | 10% |