Title |
Spatial Relational Memory Requires Hippocampal Adult Neurogenesis
|
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Published in |
PLOS ONE, April 2008
|
DOI | 10.1371/journal.pone.0001959 |
Pubmed ID | |
Authors |
David Dupret, Jean-Michel Revest, Muriel Koehl, François Ichas, Francesca De Giorgi, Pierre Costet, Djoher Nora Abrous, Pier Vincenzo Piazza |
Abstract |
The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning. |
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France | 4 | <1% |
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Other | 4 | <1% |
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Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 105 | 23% |
Researcher | 82 | 18% |
Student > Master | 73 | 16% |
Student > Bachelor | 55 | 12% |
Student > Doctoral Student | 29 | 6% |
Other | 62 | 14% |
Unknown | 49 | 11% |
Readers by discipline | Count | As % |
---|---|---|
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Neuroscience | 105 | 23% |
Medicine and Dentistry | 45 | 10% |
Psychology | 35 | 8% |
Biochemistry, Genetics and Molecular Biology | 25 | 5% |
Other | 34 | 7% |
Unknown | 57 | 13% |