| Title |
When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses
|
|---|---|
| Published in |
PLOS ONE, April 2008
|
| DOI | 10.1371/journal.pone.0001871 |
| Pubmed ID | |
| Authors |
David Gisselsson, Ulf Håkanson, Patrick Stoller, Dominik Marti, Yuesheng Jin, Anders H. Rosengren, Ylva Stewénius, Fredrik Kahl, Ioannis Panagopoulos |
| Abstract |
Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution. However, this notion has been little validated experimentally. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 66 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 32% |
| Student > Ph. D. Student | 16 | 24% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 4 | 6% |
| Professor > Associate Professor | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 51% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Medicine and Dentistry | 6 | 9% |
| Neuroscience | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 11 | 16% |