| Title |
Deletion of Genes Implicated in Protecting the Integrity of Male Germ Cells Has Differential Effects on the Incidence of DNA Breaks and Germ Cell Loss
|
|---|---|
| Published in |
PLOS ONE, October 2007
|
| DOI | 10.1371/journal.pone.0000989 |
| Pubmed ID | |
| Authors |
Catriona Paul, Joanne E. Povey, Nicola J. Lawrence, Jim Selfridge, David W. Melton, Philippa T. K. Saunders |
| Abstract |
Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarriage. Mouse models allow us to investigate how deficiencies in DNA repair/damage response pathways impact on formation and function of male germ cells. We have investigated mice with deletions of ERCC1 (excision repair cross-complementing gene 1), MSH2 (MutS homolog 2, involved in mismatch repair pathway), and p53 (tumour suppressor gene implicated in elimination of germ cells with DNA damage). |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| New Zealand | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 24% |
| Researcher | 8 | 17% |
| Professor > Associate Professor | 5 | 11% |
| Student > Postgraduate | 3 | 7% |
| Other | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 11 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 26% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Medicine and Dentistry | 5 | 11% |
| Unspecified | 1 | 2% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 7 | 15% |
| Unknown | 12 | 26% |