| Title |
The H19 Non-Coding RNA Is Essential for Human Tumor Growth
|
|---|---|
| Published in |
PLOS ONE, September 2007
|
| DOI | 10.1371/journal.pone.0000845 |
| Pubmed ID | |
| Authors |
Imad J. Matouk, Nathan DeGroot, Shaul Mezan, Suhail Ayesh, Rasha Abu-lail, Abraham Hochberg, Eithan Galun |
| Abstract |
Mutations and epigenetic aberrant signaling of growth factors pathways contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its expression is shut off in most tissues postnatally, it is re-activated during adult tissue regeneration and tumorigenesis. Moreover, H19 is highly expressed in liver metastasis derived from a range of carcinomas. The objective of this study is to explore the role of H19 in carcinogenesis, and to determine its identification as an anti-tumor target. |
Mendeley readers
The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Hungary | 1 | <1% |
| China | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 224 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 45 | 20% |
| Student > Master | 40 | 17% |
| Student > Ph. D. Student | 39 | 17% |
| Student > Bachelor | 17 | 7% |
| Professor > Associate Professor | 13 | 6% |
| Other | 37 | 16% |
| Unknown | 39 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 36% |
| Biochemistry, Genetics and Molecular Biology | 56 | 24% |
| Medicine and Dentistry | 27 | 12% |
| Immunology and Microbiology | 8 | 3% |
| Computer Science | 2 | <1% |
| Other | 11 | 5% |
| Unknown | 44 | 19% |