Title |
Lectin-Based Food Poisoning: A New Mechanism of Protein Toxicity
|
---|---|
Published in |
PLOS ONE, August 2007
|
DOI | 10.1371/journal.pone.0000687 |
Pubmed ID | |
Authors |
Katsuya Miyake, Toru Tanaka, Paul L. McNeil |
Abstract |
Ingestion of the lectins present in certain improperly cooked vegetables can result in acute GI tract distress, but the mechanism of toxicity is unknown. In vivo, gut epithelial cells are constantly exposed to mechanical and other stresses and consequently individual cells frequently experience plasma membrane disruptions. Repair of these cell surface disruptions allows the wounded cell to survive: failure results in necrotic cell death. Plasma membrane repair is mediated, in part, by an exocytotic event that adds a patch of internal membrane to the defect site. Lectins are known to inhibit exocytosis. We therefore tested the novel hypothesis that lectin toxicity is due to an inhibitory effect on plasma membrane repair. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 13% |
Djibouti | 1 | 7% |
Hungary | 1 | 7% |
Unknown | 11 | 73% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 93% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 2 | 1% |
Denmark | 1 | <1% |
Croatia | 1 | <1% |
Unknown | 138 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 18% |
Researcher | 20 | 14% |
Student > Bachelor | 19 | 13% |
Student > Ph. D. Student | 14 | 10% |
Student > Postgraduate | 9 | 6% |
Other | 28 | 20% |
Unknown | 27 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 25% |
Medicine and Dentistry | 19 | 13% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Chemistry | 10 | 7% |
Nursing and Health Professions | 6 | 4% |
Other | 24 | 17% |
Unknown | 32 | 23% |