| Title |
Secreted Sulfatases Sulf1 and Sulf2 Have Overlapping yet Essential Roles in Mouse Neonatal Survival
|
|---|---|
| Published in |
PLOS ONE, June 2007
|
| DOI | 10.1371/journal.pone.0000575 |
| Pubmed ID | |
| Authors |
Charles R. Holst, Hani Bou-Reslan, Bryan B. Gore, Karen Wong, Deanna Grant, Sreedevi Chalasani, Richard A. Carano, Gretchen D. Frantz, Marc Tessier-Lavigne, Brad Bolon, Dorothy M. French, Avi Ashkenazi |
| Abstract |
Heparan sulfate proteoglycans (HSPGs) use highly sulfated polysaccharide side-chains to interact with several key growth factors and morphogens, thereby regulating their accessibility and biological activity. Various sulfotransferases and sulfatases with differing specificities control the pattern of HSPG sulfation, which is functionally critical. Among these enzymes in the mouse are two secreted 6-O-endosulfatases, Sulf1 and Sulf2, which modify HSPGs in the extracellular matrix and on the cell surface. The roles of Sulf1 and Sulf2 during normal development are not well understood. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 3% |
| China | 1 | 1% |
| Unknown | 69 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 38% |
| Researcher | 14 | 19% |
| Professor > Associate Professor | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Professor | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 39% |
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Medicine and Dentistry | 7 | 10% |
| Neuroscience | 3 | 4% |
| Chemistry | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 15 | 21% |