| Title |
The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly
|
|---|---|
| Published in |
PLOS ONE, January 2007
|
| DOI | 10.1371/journal.pone.0000179 |
| Pubmed ID | |
| Authors |
Chen Luxenburg, Dafna Geblinger, Eugenia Klein, Karen Anderson, Dorit Hanein, Benny Geiger, Lia Addadi |
| Abstract |
Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such as osteoporosis. Osteoclasts develop specialized adhesion structures, the so-called podosomes, which subsequently undergo dramatic reorganization into sealing zones. These ring-like adhesion structures, which delimit the resorption site, effectively seal the cell to the substrate forming a diffusion barrier. The structural integrity of the sealing zone is essential for the cell ability to degrade bone, yet its structural organization is poorly understood. |
Mendeley readers
The data shown below were compiled from readership statistics for 195 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 3 | 2% |
| Netherlands | 2 | 1% |
| France | 1 | <1% |
| Japan | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 183 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 26% |
| Researcher | 38 | 19% |
| Student > Master | 20 | 10% |
| Student > Bachelor | 13 | 7% |
| Professor > Associate Professor | 13 | 7% |
| Other | 33 | 17% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 31% |
| Biochemistry, Genetics and Molecular Biology | 36 | 18% |
| Medicine and Dentistry | 20 | 10% |
| Engineering | 10 | 5% |
| Materials Science | 7 | 4% |
| Other | 27 | 14% |
| Unknown | 34 | 17% |