| Title |
At-Risk and Recent-Onset Type 1 Diabetic Subjects Have Increased Apoptosis in the CD4+CD25+high T-Cell Fraction
|
|---|---|
| Published in |
PLOS ONE, January 2007
|
| DOI | 10.1371/journal.pone.0000146 |
| Pubmed ID | |
| Authors |
Sanja Glisic-Milosavljevic, Jill Waukau, Parthav Jailwala, Srikanta Jana, Huoy-Jii Khoo, Hope Albertz, Jeffrey Woodliff, Marilyn Koppen, Ramin Alemzadeh, William Hagopian, Soumitra Ghosh |
| Abstract |
In experimental models, Type 1 diabetes T1D can be prevented by adoptive transfer of CD4+CD25+ (FoxP3+) suppressor or regulatory T cells. Recent studies have found a suppression defect of CD4+CD25+(high) T cells in human disease. In this study we measure apoptosis of CD4+CD25+(high) T cells to see if it could contribute to reduced suppressive activity of these cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 2 | 4% |
| Austria | 1 | 2% |
| Unknown | 46 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Researcher | 7 | 14% |
| Professor > Associate Professor | 6 | 12% |
| Student > Bachelor | 5 | 10% |
| Student > Master | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 27% |
| Immunology and Microbiology | 10 | 20% |
| Agricultural and Biological Sciences | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Environmental Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |