| Title |
Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal
|
|---|---|
| Published in |
PLOS ONE, December 2006
|
| DOI | 10.1371/journal.pone.0000102 |
| Pubmed ID | |
| Authors |
Fatema A. Legrand, Douglas F. Nixon, Christopher P. Loo, Erika Ono, Joan M. Chapman, Maristela Miyamoto, Ricardo S. Diaz, Amélia M.N. Santos, Regina C.M. Succi, Jacob Abadi, Michael G. Rosenberg, Maria Isabel de Moraes-Pinto, Esper G. Kallas |
| Abstract |
In utero transmission of HIV-1 occurs on average in only 3%-15% of HIV-1-exposed neonates born to mothers not on antiretroviral drug therapy. Thus, despite potential exposure, the majority of infants remain uninfected. Weak HIV-1-specific T-cell responses have been detected in children exposed to HIV-1, and potentially contribute to protection against infection. We, and others, have recently shown that the removal of CD4(+) CD25(+) T-regulatory (Treg) cells can reveal strong HIV-1 specific T-cell responses in some HIV-1 infected adults. Here, we hypothesized that Treg cells could suppress HIV-1-specific immune responses in young children. |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Belgium | 1 | 1% |
| South Africa | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 92 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Postgraduate | 12 | 13% |
| Researcher | 11 | 11% |
| Student > Master | 9 | 9% |
| Professor | 8 | 8% |
| Other | 20 | 21% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 28% |
| Agricultural and Biological Sciences | 24 | 25% |
| Immunology and Microbiology | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Business, Management and Accounting | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 18 | 19% |