| Title |
A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle
|
|---|---|
| Published in |
PLOS ONE, December 2006
|
| DOI | 10.1371/journal.pone.0000097 |
| Pubmed ID | |
| Authors |
Reijo Laaksonen, Mikko Katajamaa, Hannu Päivä, Marko Sysi-Aho, Lilli Saarinen, Päivi Junni, Dieter Lütjohann, Joél Smet, Rudy Van Coster, Tuulikki Seppänen-Laakso, Terho Lehtimäki, Juhani Soini, Matej Orešič |
| Abstract |
Aggressive lipid lowering with high doses of statins increases the risk of statin-induced myopathy. However, the cellular mechanisms leading to muscle damage are not known and sensitive biomarkers are needed to identify patients at risk of developing statin-induced serious side effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 4% |
| United Kingdom | 3 | 2% |
| Colombia | 1 | <1% |
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| Finland | 1 | <1% |
| Germany | 1 | <1% |
| Singapore | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 2 | 1% |
| Unknown | 152 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 51 | 30% |
| Student > Ph. D. Student | 29 | 17% |
| Student > Bachelor | 14 | 8% |
| Professor | 13 | 8% |
| Other | 11 | 6% |
| Other | 32 | 19% |
| Unknown | 20 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 35% |
| Medicine and Dentistry | 25 | 15% |
| Chemistry | 19 | 11% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Computer Science | 8 | 5% |
| Other | 17 | 10% |
| Unknown | 25 | 15% |