Title |
The Protective Role of Symmetric Stem Cell Division on the Accumulation of Heritable Damage
|
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Published in |
PLoS Computational Biology, August 2014
|
DOI | 10.1371/journal.pcbi.1003802 |
Pubmed ID | |
Authors |
Peter T. McHale, Arthur D. Lander |
Abstract |
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one does not-or symmetric, in which both daughter cells adopt the same fate, either stem or non-stem. Recent studies show that in many tissues operating under homeostatic conditions stem cell division patterns are strongly biased toward the symmetric outcome, raising the question of whether symmetry confers some benefit. Here, we show that symmetry, via extinction of damaged stem-cell clones, reduces the lifetime risk of accumulating phenotypically silent heritable damage (mutations or aberrant epigenetic changes) in individual stem cells. This effect is greatest in rapidly cycling tissues subject to accelerating rates of damage accumulation over time, a scenario that describes the progression of many cancers. A decrease in the rate of cellular damage accumulation may be an important factor favoring symmetric patterns of stem cell division. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
France | 1 | 3% |
Unknown | 33 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 40% |
Researcher | 10 | 29% |
Student > Bachelor | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Student > Master | 2 | 6% |
Other | 2 | 6% |
Unknown | 1 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 43% |
Biochemistry, Genetics and Molecular Biology | 7 | 20% |
Medicine and Dentistry | 3 | 9% |
Mathematics | 2 | 6% |
Physics and Astronomy | 2 | 6% |
Other | 4 | 11% |
Unknown | 2 | 6% |